Five Palestinians were killed, including two children, and several wounded when Israeli aircraft struck tents for displaced people west of Khan Younis, according to medics at the Kuwait Field Hospital.
The strikes hit Gaza's coastal al-Mawasi area.
Medical teams said the dead included two women aged 46 and 30, a 36-year-old man, and two boys, ages eight and ten.
About 32 injured individuals received treatment at local hospitals.
Rescue workers reported recovering the bodies from al-Najaat camp, which has sheltered hundreds of displaced people in recent months.
The Israeli military stated it had struck a Hamas terrorist after five of its soldiers were injured earlier that day.
The Hamas terrorist organization carried out a blatant violation of the ceasefire agreement, during which terrorists attacked IDF troops deployed in the Rafah area, the Israel Defense Forces said in a statement.
Israeli Prime Minister Benjamin Netanyahu had vowed to respond accordingly to the situation.
Witnesses recounted initial explosions targeting a tent in the al-Mawasi area, with subsequent blasts occurring near the Kuwait hospital, inducing panic among nearby families.
Hamas condemned Israel's actions as barbaric, indiscriminate, and a breach of the ceasefire which began on October 10.
This military offensive follows a Hamas-led attack on southern Israel on October 7, resulting in around 1,200 deaths and 251 hostages taken.
The Hamas-run health ministry reported that over 70,100 Palestinians have been killed as a result of Israel's ongoing military campaign.
