Italy's Prime Minister Giorgia Meloni has lost a key referendum on a constitutional reform which had turned into a vote on her government. The result gave around 54% to the 'No' campaign and 46% to the 'Yes' vote, which Meloni had backed. In a video posted on social media before all ballots were counted, Meloni acknowledged the clarity of the voters' decision but regretted a lost chance to modernize the country.

This marks her first significant defeat since taking office, amidst a rare period of political stability which now faces uncertainty. Opposition parties are celebrating the result as an indicator that voters are seeking change, especially with a general election upcoming.

Turnout for the referendum was nearly 60%, which was higher than expected, but still not enough to secure a win for the government. The reform proposed to establish a firm separation between judges and prosecutors but was criticized for potentially undermining established checks and balances.

Meloni remains steadfast and does not intend to resign, stating the vote was more about justice than her leadership. However, analysts suggest her government needs to listen to the electorate more closely after this loss, reflecting a shift in public sentiment.